Differential transcriptional responses of keloid and normal keratinocytes to serum stimulation.

@article{Xia2006DifferentialTR,
  title={Differential transcriptional responses of keloid and normal keratinocytes to serum stimulation.},
  author={Wei Xia and Toan Thang Phan and Ivor Jiun Lim and Michael Thornton Longaker and George P. Yang},
  journal={The Journal of surgical research},
  year={2006},
  volume={135 1},
  pages={
          156-63
        }
}
BACKGROUND Keloids are benign tumors that occur only in response to injury, for which there is no effective treatment. We demonstrated previously that keloid keratinocytes (KKs) promote fibroblast proliferation more than normal keratinocytes (NKs) and that transforming growth factor (TGF)-beta is a component of that signal. We used the transcriptional response to serum stimulation to examine how TGF-beta expression is stimulated in KKs. MATERIALS AND METHODS Quiescent KKs and NKs were… CONTINUE READING

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Mentioned Connections BETA
Transcription, GeneticBiological process results from biological processTranscriptional Activation
Inhibition of the ERK , p38 kinase or JNK signal transduction pathways blocked the transcriptional up - regulation of TGF - beta2 , TbetaR1 , and TbetaR2 in KKs .
Increased TGF - beta2 mRNA correlated with increased TGF - beta biological activity in the conditioned medium .
KKs produce more TGF - beta2 mRNA than NKs in response to serum stimulation , resulting in increased TGF - beta activity in conditioned medium .
Increased TGF - beta2 mRNA correlated with increased TGF - beta biological activity in the conditioned medium .
KKs produce more TGF - beta2 mRNA than NKs in response to serum stimulation , resulting in increased TGF - beta activity in conditioned medium .
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