Differential trafficking of saccharidic probes following aspirin in clinical tests of intestinal permeability in young healthy women

@article{Sequeira2014DifferentialTO,
  title={Differential trafficking of saccharidic probes following aspirin in clinical tests of intestinal permeability in young healthy women},
  author={Ivana R Sequeira and Roger G Lentle and Marlena Cathorina Kruger and Roger Hurst},
  journal={Clinical and Experimental Pharmacology and Physiology},
  year={2014},
  volume={41}
}
The effects of inflammatory changes on the absorption of different‐sized probes and their permeability ratios are poorly understood. The aim of the present study was to determine the effects of a pharmacological agent on the permeability of the gut mucosa to saccharidic probes of larger and smaller molecular weight. Permeability was assessed by half‐hourly urinary excretion of a combined dose of d‐mannitol, l‐rhamnose and lactulose following consumption of a single 600 mg dose of aspirin and… Expand
Aspirin-induced increase in intestinal paracellular permeability does not affect the levels of LPS in venous blood of healthy women
TLDR
This data indicates that aspirin-induced damage of the small intestinal mucosa, evidenced by an increase in the paracellular permeability, allows greater transit of LPS into the systemic circulation, and there was no correlation between body fat content and circulating levels of L PS. Expand
Standardising the Lactulose Mannitol Test of Gut Permeability to Minimise Error and Promote Comparability
TLDR
The results indicate that between subject variation in the percentage excretion of the two sugars would be minimised and the differences in the temporal patterns of excretion would be maximised if the period of collection of urine used in clinical tests of small intestinal permeability were restricted to 2½-4 h post dosage. Expand
Assessment of the Effect of Intestinal Permeability Probes (Lactulose And Mannitol) and Other Liquids on Digesta Residence Times in Various Segments of the Gut Determined by Wireless Motility Capsule: A Randomised Controlled Trial
TLDR
The negatively exponential profile and lack of any peaks in the frequency spectra of cyclic variation in gastric intraluminal pressure that were consistent with reported physiological frequencies of contractile activity profile suggests that the principal source of this variation is stochastic likely resulting from the effects of external events occasioned by normal daily activities on intra-abdominal pressure. Expand
Clinical tests for intestinal permeability: ‘Sweet’ transition from clinical to basic physiology
TLDR
Clinical tests for intestinal permeability are a remarkably useful tool for the assessment of the recovery of the intestinal barrier after inflammatory conditions accompanying the associated diseases, such as inflammatory bowel disease, Crohn’s disease and rheumatoid arthritis. Expand
A method for assessing real time rates of dissolution and absorption of carbohydrate and other food matrices in human subjects.
TLDR
Feeding test foods impregnated with lactulose and mannitol probes provided a reproducible and practical means of assessing the timing of digestion of the carbohydrate matrix and showed that this was more protracted than suggested by post prandial glucose levels. Expand
The Effects of Exercise on Indirect Markers of Gut Damage and Permeability: A Systematic Review and Meta-analysis
TLDR
It is demonstrated that a single bout of exercise increases gut damage and gut permeability in healthy participants, with gut damage being exacerbated in hot environments. Expand
Intestinal Permeability Assays: a Review
Aim. A literature review of intestinal permeability assessment techniques.Key points. The intestinal barrier is a functional entity separating the intestinal lumen and internal body, and intestinalExpand
Ascorbic Acid may Exacerbate Aspirin‐Induced Increase in Intestinal Permeability
TLDR
It is indicated that ascorbic acid does not prevent aspirin‐induced increase in gut permeability rather that both agents augment it to a similar extent and the additive effect on simultaneous dosage with both agents in augmenting the absorption of lactulose suggests that each influences paracellular permeability by different pathways. Expand
Palmitoylethanolamide and Cannabidiol Prevent Inflammation-induced Hyperpermeability of the Human Gut In Vitro and In Vivo-A Randomized, Placebo-controlled, Double-blind Controlled Trial.
TLDR
Cannabidiol and palmitoylethanolamide reduce permeability in the human colon and have implications in disorders associated with increased gut permeability, such as inflammatory bowel disease. Expand
The complex task of measuring intestinal permeability in basic and clinical science
  • H. Galipeau, E. Verdu
  • Biology, Medicine
  • Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2016
TLDR
This mini‐review will highlight the advantages and limitations associated with intestinal permeability tests and will identify current problems in the field and how they can be addressed in the future. Expand

References

SHOWING 1-10 OF 58 REFERENCES
Polyethylene glycol versus dual sugar assay for gastrointestinal permeability analysis: is it time to choose?
TLDR
A double-blinded crossover study to evaluate probe excretion and accuracy of a polyethylene glycol (PEG) assay and dual sugar assay and demonstrates equivalent performance in the current setting improves knowledge of permeability analysis in man. Expand
Molecular radii of probes used in studies of intestinal permeability.
TLDR
With the exception of the value given for the chromiumEDTA complex, effective hydrodynamic radii for uncharged molecules in dilute aqueous solution have been determined by viscometry through use of the Stokes-Einstein equation. Expand
Intestinal permeability and screening tests for coeliac disease.
TLDR
A study of its application as a screening procedure for coeliac disease showed that the test was both sensitive and accurate, with fewer false-positive and false-negative results than other recognised screening tests--namely, the xylose test, reticulin antibodies, and blood folate estimations. Expand
The sensitivity of the lactulose/rhamnose gut permeability test
TLDR
If the permeability is increased, the urinary L/R ratio depends on the quantity of lactulose and rhamnose administered in equal proportion, and 5L to 0.5R is sufficient to discriminate between a normal and a moderately increased permeability. Expand
Novel multi-sugar assay for site-specific gastrointestinal permeability analysis: a randomized controlled crossover trial.
TLDR
The multi-sugar test provides accurate, site-specific information on gastroduodenal, small, and large intestinal permeability, and in contrast to the DS test, monosaccharide excretion is not decreased by the MS test. Expand
Understanding measurements of intestinal permeability in healthy humans with urine lactulose and mannitol excretion
  • M. Camilleri, A. Nadeau, +6 authors R. Singh
  • Chemistry, Medicine
  • Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2010
TLDR
It is concluded that, after LF, sugar excretion in 0–2’h urine may reflect both SI and colon permeability; the higher LMR in the 8–24 h urine relative to 0-2“h urine should be interpreted with caution and does not mean that colon is more permeable than SI. Expand
Effect of aspirin dose on gastrointestinal permeability.
TLDR
The data indicated that the menstrual cycle had no effect on GI permeability, and healthy individuals should be cautious even with acute aspirin use as it may result in GI barrier dysfunction. Expand
Increased intestinal permeability in patients with inflammatory bowel disease.
TLDR
Patients with Crohn's disease or with ulcerative colitis had increased permeability indices in comparison to healthy controls, even in remission, and the L/R ratio gave a better differentiation between the healthy controls and patients with active disease than the other agents. Expand
Intestinal permeability in coeliac disease: the response to gluten withdrawal and single-dose gluten challenge.
TLDR
The cellobiose/mannitol ratio appears to be of value in assessing the response to gluten withdrawal in coeliac disease, and also in monitoring patients who are already established on a gluten free diet by detecting dietary lapses and 'non-responding coeliat disease'. Expand
Comparison of four markers of intestinal permeability in control subjects and patients with coeliac disease.
TLDR
Correlations of marker permeation rates with test dose osmolarity in controls and patients with coeliac disease shows a variable lack of conformity, suggesting that the markers may permeate the intestine by different routes, which are affected to a different extent in coeliat disease. Expand
...
1
2
3
4
5
...