Differential tissue sensitivity to elevated endogenous insulin levels during experimental peritonitis in rats.

@article{Ryan1974DifferentialTS,
  title={Differential tissue sensitivity to elevated endogenous insulin levels during experimental peritonitis in rats.},
  author={Neal Ryan and George L. Blackburn and H A Clowes},
  journal={Metabolism: clinical and experimental},
  year={1974},
  volume={23 11},
  pages={1081-9}
}
Disturbances of glucose metabolism consequent to experimental peritonitis in rats were studied by measurement of insulinrelated metabolism of isolated tissues in correlation with blood insulin and substrate levels. Blood insulin concentrations were threefold higher in infected fasting rats than in normal fasting controls, despite approximately equal blood glucose concentrations, suggesting resistance to the hypoglycemic action of insulin. The increased circulating insulin was associated with a… CONTINUE READING