Differential tissue regulation of insulin-like growth factor-I content and binding proteins after endotoxin.

@article{Fan1994DifferentialTR,
  title={Differential tissue regulation of insulin-like growth factor-I content and binding proteins after endotoxin.},
  author={Jia Ren Fan and Patricia E Molina and Marie C. Gelato and Charles H Lang},
  journal={Endocrinology},
  year={1994},
  volume={134 4},
  pages={1685-92}
}
The purpose of the present study was to investigate the regulation of plasma and tissue levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-1, -2, and -3 (IGFBP-1, -2, and -3) in rats injected with Escherichia coli lipopolysaccharide (LPS), a component of the outer cell wall of gram-negative bacteria. When injected iv into conscious overnight fasted rats, plasma IGF-I levels were initially decreased within 1 h, maximally depressed at 4 h, and still only 35-45% of control… CONTINUE READING
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