Differential time course of action of 5-HT3 and NK1 receptor antagonists when used with highly and moderately emetogenic chemotherapy (HEC and MEC)

@article{Hesketh2010DifferentialTC,
  title={Differential time course of action of 5-HT3 and NK1 receptor antagonists when used with highly and moderately emetogenic chemotherapy (HEC and MEC)},
  author={Paul Joseph Hesketh and David G. Warr and James C. Street and Alexandra D. Carides},
  journal={Supportive Care in Cancer},
  year={2010},
  volume={19},
  pages={1297-1302}
}
Cisplatin-based highly emetogenic chemotherapy (HEC) displays a biphasic pattern of emesis with both an early and delayed period. In contrast, moderately emetogenic chemotherapy (MEC) has a monophasic pattern. The objective of this analysis was to further investigate the impact of the NK1-receptor antagonist aprepitant on these patterns. Three phase III HEC (patients scheduled to receive cisplatin-based chemotherapy) and one phase III MEC (breast cancer patients scheduled to receive… CONTINUE READING
5 Citations
18 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 18 references

Similar Papers

Loading similar papers…