Differential thiol oxidation of the signaling proteins Akt, PTEN or PP2A determines whether Akt phosphorylation is enhanced or inhibited by oxidative stress in C2C12 myotubes derived from skeletal muscle.

@article{Tan2015DifferentialTO,
  title={Differential thiol oxidation of the signaling proteins Akt, PTEN or PP2A determines whether Akt phosphorylation is enhanced or inhibited by oxidative stress in C2C12 myotubes derived from skeletal muscle.},
  author={Pearl Lin Tan and Tea Shavlakadze and Miranda D Grounds and Peter G Arthur},
  journal={The international journal of biochemistry & cell biology},
  year={2015},
  volume={62},
  pages={72-9}
}
Oxidative stress, caused by excess reactive oxygen species (ROS), has been hypothesized to cause or exacerbate skeletal muscle wasting in a number of diseases and chronic conditions. ROS, such as hydrogen peroxide, have the potential to affect signal transduction pathways such as the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3 K)/Akt pathway that regulates protein synthesis. Previous studies have found contradictory outcomes for the effect of ROS on the PI3K/Akt signaling pathway, where… CONTINUE READING
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aging muscle and oxidative system pathway. Oxidative Medicine and Cellular Longevity

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