Differential tetraethylammonium sensitivity of KCNQ1-4 potassium channels.

@article{Hadley2000DifferentialTS,
  title={Differential tetraethylammonium sensitivity of KCNQ1-4 potassium channels.},
  author={Jennifer K Hadley and Masaharu Noda and Alexander A. Selyanko and Ian C Wood and Fe C. Abogadie and David Brown},
  journal={British journal of pharmacology},
  year={2000},
  volume={129 3},
  pages={
          413-5
        }
}
In Shaker-group potassium channels the presence of a tyrosine residue, just downstream of the pore signature sequence GYG, determines sensitivity to tetraethylammonium (TEA). The KCNQ family of channels has a variety of amino acid residues in the equivalent position. We studied the effect of TEA on currents generated by KCNQ homomers and heteromers expressed in CHO cells. We used wild-type KCNQ1-4 channels and heteromeric KCNQ2/3 channels incorporating either wild-type KCNQ3 subunits or a… CONTINUE READING
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