Differential telomerase activity, expression of the telomerase catalytic sub-unit and telomerase-RNA in ovarian tumors.

@article{Park1999DifferentialTA,
  title={Differential telomerase activity, expression of the telomerase catalytic sub-unit and telomerase-RNA in ovarian tumors.},
  author={Tae Wook Park and Sabine Riethdorf and Lutz Riethdorf and Thomas Loening and F. J{\"a}nicke},
  journal={International journal of cancer},
  year={1999},
  volume={84 4},
  pages={426-31}
}
Telomerase activity has been found in a variety of malignant tumors but only rarely in benign tumors or normal tissues. In this study, we investigated telomerase activation in 37 ovarian tumors, including benign, borderline and malignant neoplasms. Telomerase activity was detected using the telomeric repeat amplification protocol (TRAP) in 13/16 ovarian carcinomas, 9/10 borderline tumors and 3/11 cystadenomas/fibromas. mRNA expression of the putative human telomerase catalytic sub-unit gene… CONTINUE READING