Differential target molecules for toxicity induced by streptozotocin and alloxan in pancreatic islets of mice in vitro.

@article{Gai2004DifferentialTM,
  title={Differential target molecules for toxicity induced by streptozotocin and alloxan in pancreatic islets of mice in vitro.},
  author={Weiping Gai and Patricia Schott-Ohly and Sabine Schulte im Walde and Helga Gleichmann},
  journal={Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association},
  year={2004},
  volume={112 1},
  pages={
          29-37
        }
}
Streptozotocin (STZ) and alloxan (ALX) are potent diabetogens in different species of laboratory animals. Here, we describe differential in vitro effects of STZ and ALX on beta-cell molecules that are essential for glucose transport and metabolism, the glucose transporter 2 (GLUT2) and glucokinase (GK), respectively. Incubation of isolated pancreatic islets of C57 BL/6 mice with STZ or ALX for 30 min resulted in a concentration-dependent gradual loss of beta-cell function as determined by basal… CONTINUE READING
BETA

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