Differential susceptibility to ozone-induced airways hyperreactivity in inbred strains of mice.

@article{Zhang1995DifferentialST,
  title={Differential susceptibility to ozone-induced airways hyperreactivity in inbred strains of mice.},
  author={Lin Zhang and Roy C Levitt and Steven R. Kleeberger},
  journal={Experimental lung research},
  year={1995},
  volume={21 4},
  pages={503-18}
}
Individuals with heightened airways reactivity, such as asthmatics, may be at risk to inflammatory effects of oxidant air pollutants. In the inbred mouse, significant interstrain variation in airways reactivity to acelycholine (ACh) and differential susceptibility to ozone (O3)-induced airways inflammation has been described previously. This study used these murine models to test hypotheses that (1) O3-induced hyperreactivity to ACh is a function of inherent baseline ACh reactivity, and (2… CONTINUE READING

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