Differential susceptibility to human immunodeficiency virus type 1 infection of myeloid and plasmacytoid dendritic cells.

@article{SmedSrensen2005DifferentialST,
  title={Differential susceptibility to human immunodeficiency virus type 1 infection of myeloid and plasmacytoid dendritic cells.},
  author={Anna Smed-S{\"o}rensen and Karin Lor{\'e} and Jayanand Vasudevan and Mark K. Louder and Jan Olof Andersson and John R. Mascola and A L Spetz and Richard A. Koup},
  journal={Journal of virology},
  year={2005},
  volume={79 14},
  pages={8861-9}
}
Human immunodeficiency virus type 1 (HIV-1) infection of dendritic cells (DCs) plays an important role in HIV-1 transmission and pathogenesis. Here, we studied the susceptibility of ex vivo-isolated CD11c+ myeloid DCs (MDCs) and CD123+ plasmacytoid DCs (PDCs) to HIV-1 infection and the function of these cells early after infection. Both DC subsets were susceptible to CCR5- and CXCR4-using HIV-1 isolates (BaL and IIIB, respectively). However, MDCs were more susceptible to HIV-1(BaL) infection… CONTINUE READING
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