Differential susceptibility of retinal ganglion cells to reactive oxygen species.

  title={Differential susceptibility of retinal ganglion cells to reactive oxygen species.},
  author={K R Kortuem and Leann Geiger and Leonard A Levin},
  journal={Investigative ophthalmology & visual science},
  volume={41 10},
PURPOSE Retinal light exposure is a source of oxidative stress, and retinal cells contain molecules that scavenge or inactivate reactive oxygen species (ROS). Yet, ROS also play a role in signal transduction, and some retinal cells (e.g., neurotrophin-dependent retinal ganglion cells, RGCs) may use ROS as part of the signaling process for cell death. RGCs might therefore have specialized mechanisms for regulating ROS levels. The hypothesis that RGCs might regulate ROS differently from other… CONTINUE READING


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