Differential susceptibility of naïve and activated human gammadelta T cells to activation-induced cell death by T-cell receptor cross-linking.

@article{Gan2001DifferentialSO,
  title={Differential susceptibility of na{\"i}ve and activated human gammadelta T cells to activation-induced cell death by T-cell receptor cross-linking.},
  author={Y H Gan and Steven S. Lui and Miroslav Malkovsk{\'y}},
  journal={Molecular medicine},
  year={2001},
  volume={7 9},
  pages={
          636-43
        }
}
BACKGROUND T cells undergo activation-induced cell death (AICD) through repeated stimulation of their T cell receptors (TCRs). Activated human gammadelta T cells were found to die by apoptosis when their TCRs were cross-linked by antibodies, whereas naïve gammadelta T cells freshly isolated from blood did not. Therefore, we investigated the factors that could contribute to this differential susceptibility. MATERIALS AND METHODS Gammadelta T cells were isolated from the peripheral blood of… CONTINUE READING

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