Differential susceptibility of activated macrophage cytotoxic effector reactions to the suppressive effects of transforming growth factor-beta 1.

@article{Nelson1991DifferentialSO,
  title={Differential susceptibility of activated macrophage cytotoxic effector reactions to the suppressive effects of transforming growth factor-beta 1.},
  author={Brandy J Nelson and Peter Ralph and Shawn J. Green and Carol A. Nacy},
  journal={Journal of immunology},
  year={1991},
  volume={146 6},
  pages={1849-57}
}
We examined the effects of TGF-beta 1 on induction of several activated macrophage antimicrobial activities against the protozoan parasite Leishmania, and on induction of tumoricidal activity against the fibrosarcoma tumor target 1023. TGF-beta by itself did not affect the viability of either the intracellular or extracellular target in concentrations up to 200 ng/ml. As little as 1 ng/ml TGF-beta, however, suppressed more than 70% of the intracellular killing activity of macrophages treated… CONTINUE READING
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