Differential susceptibility of RAE-1 isoforms to mouse cytomegalovirus.

@article{Arapovi2009DifferentialSO,
  title={Differential susceptibility of RAE-1 isoforms to mouse cytomegalovirus.},
  author={Jurica Arapovi{\'c} and Tihana Lenac and Ronald Antulov and Bojan Poli{\'c} and Zsolt Ruzsics and Leonidas N. Carayannopoulos and Ulrich Koszinowski and Astrid Krmpotic and Stipan Jonji{\'c}},
  journal={Journal of virology},
  year={2009},
  volume={83 16},
  pages={
          8198-207
        }
}
The NKG2D receptor is one of the most potent activating natural killer cell receptors involved in antiviral responses. The mouse NKG2D ligands MULT-1, RAE-1, and H60 are regulated by murine cytomegalovirus (MCMV) proteins m145, m152, and m155, respectively. In addition, the m138 protein interferes with the expression of both MULT-1 and H60. We show here that one of five RAE-1 isoforms, RAE-1delta, is resistant to downregulation by MCMV and that this escape has functional importance in vivo… CONTINUE READING

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