Differential suppressive effect of promyelocytic leukemia protein on the replication of different subtypes/strains of influenza A virus.

@article{Li2009DifferentialSE,
  title={Differential suppressive effect of promyelocytic leukemia protein on the replication of different subtypes/strains of influenza A virus.},
  author={Weizhong Li and Gefei Wang and Heng Zhang and Dangui Zhang and Jun Zeng and Xiao-xuan Chen and Yan-xuan Xu and Kangsheng Li},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={389 1},
  pages={84-9}
}
Promyelocytic leukemia protein (PML) plays an important role in the defense against a number of viruses, including influenza A virus. However, the sensitivity of influenza A virus subtypes/strains to PML is unknown. We investigated the role of PML in the replication of different influenza A virus subtypes/strains using pan-PML knock-down A549 cells and PML-VI-overexpressed MDCK cells. We found that (i) depletion of pan-PML by siRNA rendered A549 cells more susceptible to influenza A virus… CONTINUE READING
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