Differential subcellular distribution of mortalin in mortal and immortal mouse and human fibroblasts.

@article{Wadhwa1993DifferentialSD,
  title={Differential subcellular distribution of mortalin in mortal and immortal mouse and human fibroblasts.},
  author={Renu Wadhwa and Sunil C. Kaul and Youji Mitsui and Yoshikazu Sugimoto},
  journal={Experimental cell research},
  year={1993},
  volume={207 2},
  pages={442-8}
}
Mortalin, p66mot-1, from the cytosolic fractions of mouse embryonic fibroblasts (MEF) has been identified. We have cloned and characterized it as a novel member of mouse hsp70 family [R. Wadhwa, S. C. Kaul, Y. Ikawa, and Y. Sugimoto (1993) J. Biol. Chem. 268, 6615-6621]. We report that immortal clones from MEF such as NIH 3T3, RS4, and Balb/c 3T3 harbor the same or a very similar protein but in the perinuclear locale. Biochemical analysis revealed that the proteins from mortal (MEF) and… CONTINUE READING

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