Differential subcellular distribution of endosomal compartments and the dopamine transporter in dopaminergic neurons.

@article{Rao2011DifferentialSD,
  title={Differential subcellular distribution of endosomal compartments and the dopamine transporter in dopaminergic neurons.},
  author={Anjali K Rao and Diana Simmons and Alexander Sorkin},
  journal={Molecular and cellular neurosciences},
  year={2011},
  volume={46 1},
  pages={148-58}
}
Dopamine (DA) transporter (DAT) functions at the surface of dopaminergic neurons to clear extracellular DA. DAT surface levels are regulated by endocytosis. However, the endosome-lysosome system is not well characterized in dopaminergic neurons and the endocytic trafficking of endogenous DAT is poorly studied. Hence we analyzed the distribution of endocytic compartments and DAT localization in cultured rat embryonic and postnatal neurons using fluorescence microscopy. Early Rab5 and EEA.1… CONTINUE READING

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