Differential sub-nuclear localisation of repressive and activating histone methyl modifications in P. falciparum.

@article{Issar2009DifferentialSL,
  title={Differential sub-nuclear localisation of repressive and activating histone methyl modifications in P. falciparum.},
  author={Neha Issar and Stuart A. Ralph and Liliana M{\^a}ncio-Silva and Catherine Keeling and Artur Scherf},
  journal={Microbes and infection},
  year={2009},
  volume={11 3},
  pages={
          403-7
        }
}
Post-translational histone modifications and sub-nuclear organization epigenetically influence gene regulation, especially those implicated in antigenic variation of Plasmodium falciparum. Here we screened for histone methylation modifications and determined, for the first time, their spatial nuclear localisation. Differential enrichment in sub-nuclear compartments, suggesting high local concentrations of particular methyl marks was observed. H3-K79me3 particularly, does not co-localise with… CONTINUE READING
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