Differential structural properties and expression patterns suggest functional significance for multiple mouse desmoglein 1 isoforms.

@article{Brennan2004DifferentialSP,
  title={Differential structural properties and expression patterns suggest functional significance for multiple mouse desmoglein 1 isoforms.},
  author={Donna Brennan and Ying Hu and Ana Kljuic and Yoowon Choi and Sohaila Joubeh and Marisa Bashkin and James K. Wahl and Andrzej Fertala and Leena Pulkkinen and Jouni Uitto and Angela M. Christiano and Andrey A Panteleyev and Mỹ G. Mahoney},
  journal={Differentiation; research in biological diversity},
  year={2004},
  volume={72 8},
  pages={
          434-49
        }
}
The four isoforms of desmosomal cadherin desmogleins (Dsg1-4) are expressed in epithelial tissues in a differentiation-specific manner. Extensive sequencing of the human genome has revealed only one copy of the Dsg1 gene. However, we recently cloned two novel additional mouse Dsg1 genes, Dsg1-beta and -gamma, which flank the original Dsg1-alpha on chromosome 18. Sequence conservation between the Dsg1 isoforms diverged significantly at exon 11, particularly in the region that encodes for the… CONTINUE READING
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