Differential stringent responses of Streptomyces coelicolor M600 to starvation of specific nutrients.

  title={Differential stringent responses of Streptomyces coelicolor M600 to starvation of specific nutrients.},
  author={Yong-Gu Ryu and Eun-Sook Kim and Dae-Wi Kim and Sung-Keun Kim and Kye Joon Lee},
  journal={Journal of microbiology and biotechnology},
  volume={17 2},
This study focused on the involvement of the unusual nucleotide (p)ppGpp, a stringent factor, during the morphological and physiological differentiation of Streptomyces coelicolor. Two genes, relA and rshA, were disrupted to demonstrate the roles of the stringent factor in the differentiation. The intracellular concentration of (p)ppGpp in the wild-type (M600) and disrupted mutants was measured in relation to the intentional starvation of a specific nutrient such as carbon, nitrogen, and… CONTINUE READING


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