Differential striatal spine pathology in Parkinson's disease and cocaine addiction: a key role of dopamine?

@article{Villalba2013DifferentialSS,
  title={Differential striatal spine pathology in Parkinson's disease and cocaine addiction: a key role of dopamine?},
  author={Rosa M Villalba and Yoland Smith},
  journal={Neuroscience},
  year={2013},
  volume={251},
  pages={2-20}
}
In the striatum, the dendritic tree of the two main populations of projection neurons, called "medium spiny neurons (MSNs)", are covered with spines that receive glutamatergic inputs from the cerebral cortex and thalamus. In Parkinson's disease (PD), striatal MSNs undergo an important loss of dendritic spines, whereas aberrant overgrowth of striatal spines occurs following chronic cocaine exposure. This review examines the possibility that opposite dopamine dysregulation is one of the key… CONTINUE READING

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