Differential stress-induced alterations in tryptophan hydroxylase activity and serotonin turnover in two inbred mouse strains.

Abstract

Chronic stress and alterations in the serotonergic system are key predisposing factors to the development of major depression. Tryptophan hydroxylase (TPH) is the key enzyme in the biosynthesis of serotonin (5-HT). The effects of chronic stress on TPH activity remain uncertain. The BALB/c strain is stress-sensitive, highly anxious and possess a single… (More)
DOI: 10.1016/j.neuropharm.2010.11.020

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