Differential staining of DNA strand breaks in dying cells by non-radioactive in situ nick translation.

@article{Hashimoto1995DifferentialSO,
  title={Differential staining of DNA strand breaks in dying cells by non-radioactive in situ nick translation.},
  author={Shu Hashimoto and Takehiko Koji and Ju-wei Niu and Takashi Kanematsu and Paul K. Nakane},
  journal={Archives of histology and cytology},
  year={1995},
  volume={58 2},
  pages={
          161-70
        }
}
Various lines of evidence indicate the involvement of DNA strand breaks (DSB) in the regulation of physiological states of cells, especially in cell death. Currently, cell death is divided into two categories, apoptosis and necrosis. As lysosomal integrity is maintained in apoptosis, while disrupted in necrosis, it is possible to assume that necrotic chromatin is exposed to digestion by various lysosomal enzymes. We have therefore investigated whether apoptotic DSB and necrotic DSB can be… CONTINUE READING

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