Differential splicing of antigen-encoding RNA reduces endogenous epitope presentation that regulates the expansion and cytotoxicity of T cells.

Abstract

The activation of CTLs is dependent on the recognition of MHC-bound peptide present on the surface of APCs. We give evidence in this study that differential splicing of Ag-encoding RNA can decrease the antigenic dose in APCs and regulate the recall of human memory CTLs. Differential splicing of RNA that encoded an immunodominant HLA-B8-restricted CTL… (More)

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@article{Kienzle2000DifferentialSO, title={Differential splicing of antigen-encoding RNA reduces endogenous epitope presentation that regulates the expansion and cytotoxicity of T cells.}, author={Norbert Kienzle and Michael J. Buck and Sarah Silins and Sally Burrows and D. J. Moss and Adam C Winterhalter and A. Brooks and Rohit Khanna}, journal={Journal of immunology}, year={2000}, volume={165 4}, pages={1840-6} }