Differential sorting and fate of endocytosed GPI-anchored proteins.

@article{Fivaz2002DifferentialSA,
  title={Differential sorting and fate of endocytosed GPI-anchored proteins.},
  author={Marc Fivaz and Francis Vilbois and Sarah Thurnheer and Christian Pasquali and Laurence Abrami and Perry E Bickel and Robert G. Parton and F Gisou van der Goot},
  journal={The EMBO journal},
  year={2002},
  volume={21 15},
  pages={3989-4000}
}
In this paper, we studied the fate of endocytosed glycosylphosphatidyl inositol anchored proteins (GPI- APs) in mammalian cells, using aerolysin, a bacterial toxin that binds to the GPI anchor, as a probe. We find that GPI-APs are transported down the endocytic pathway to reducing late endosomes in BHK cells, using biochemical, morphological and functional approaches. We also find that this transport correlates with the association to raft-like membranes and thus that lipid rafts are present in… CONTINUE READING
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