Differential single- versus double-strand DNA breakage produced by doxorubicin and its morpholinyl analogues

@article{Duran1996DifferentialSV,
  title={Differential single- versus double-strand DNA breakage produced by doxorubicin and its morpholinyl analogues},
  author={George E Duran and Derick H. M. Lau and Alexander Dodge Lewis and J.-S. K{\"u}hl and Theodor K. B{\"a}mmler and Branimir Sikic},
  journal={Cancer Chemotherapy and Pharmacology},
  year={1996},
  volume={38},
  pages={210-216}
}
Abstract The morpholinyl analogues of doxorubicin (DOX) have previously been reported to be non-cross-resistant in multidrug resistant (MDR) cells due to a lower affinity for P-glycoprotein relative to the parent compound. In order to further investigate the mechanisms of action of these morpholinyl anthracyclines, we examined their ability to cause DNA single- and double-strand breaks (SSB, DSB) and their interactions with topoisomerases. Alkaline elution curves were determined after 2-h drug… CONTINUE READING
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