Differential signaling of the endogenous agonists at the beta2-adrenergic receptor.

@article{Reiner2010DifferentialSO,
  title={Differential signaling of the endogenous agonists at the beta2-adrenergic receptor.},
  author={Susanne Reiner and Manuela Ambrosio and Carsten Hoffmann and Martin J. Lohse},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 46},
  pages={36188-98}
}
The concept of "functional selectivity" or "biased signaling" suggests that a ligand can have distinct efficacies with regard to different signaling pathways. We have investigated the question of whether biased signaling may be related to distinct agonist-induced conformational changes in receptors using the β(2)-adrenergic receptor (β(2)AR) and its two endogenous ligands epinephrine and norepinephrine as a model system. Agonist-induced conformational changes were determined in a fluorescently… CONTINUE READING