Differential signaling of sphingosine derivatives in U937 human monocytes depends on the degree of N-methylation.

@article{Kim2008DifferentialSO,
  title={Differential signaling of sphingosine derivatives in U937 human monocytes depends on the degree of N-methylation.},
  author={Hyo-lim Kim and Mijin Han and D. B. Im},
  journal={Prostaglandins & other lipid mediators},
  year={2008},
  volume={86 1-4},
  pages={68-72}
}
Previously, we studied N,N-dimethyl-D-erythro-sphingosine (DMS)-induced cell death and signaling in U937 human monocytes; we found that DMS-induced sphingosine kinase- and PKC-independent apoptosis. In the present study, we studied apoptotic responses by three N-methyl derivatives of sphingosine: N-monomethyl-D-erythro-sphingosine (MMS), N,N,N-trimethyl-D… CONTINUE READING