Differential signaling by the thromboxane receptor isoforms via the novel GTP-binding protein, Gh.

@article{Vezza1999DifferentialSB,
  title={Differential signaling by the thromboxane receptor isoforms via the novel GTP-binding protein, Gh.},
  author={Roberta Vezza and Ahmed Habib and Garret A. FitzGerald},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 18},
  pages={12774-9}
}
Thromboxane A2 acts via G protein-coupled receptors; two splice variants of the thromboxane A2 receptor (TPalpha and TPbeta) have been cloned. It is unknown whether they differ in their capacity to activate intracellular signaling pathways. Recently, a high molecular weight G protein, Gh, that can also function as a tissue transglutaminase, has been described. We investigated whether Gh functions as a signaling protein in association with thromboxane receptors. First, we sought Gh expression in… CONTINUE READING
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