Differential sensitization by orobol in proliferating and quiescent human ovarian carcinoma cells.

Abstract

The object of this study was to determine how phosphatidylinositol (PI) signaling pathway is involved in the regulation of cisplatin (DDP) sensitivity. Clonogenic survival assay was used to determine the effect of orobol, a potent PI4-kinase inhibitor, on DDP sensitivity in human ovarian carcinoma 2008 cells. Orobol enhanced sensitivity to DDP in 2008 cells… (More)

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@article{Shiotsuka2001DifferentialSB, title={Differential sensitization by orobol in proliferating and quiescent human ovarian carcinoma cells.}, author={Shoichi Shiotsuka and S. Isonishi}, journal={International journal of oncology}, year={2001}, volume={18 2}, pages={337-42} }