Differential sensitivity of the microtubule-associated protein, tau, in Alzheimer's disease tissue to formalin fixation.

@article{Pollock1988DifferentialSO,
  title={Differential sensitivity of the microtubule-associated protein, tau, in Alzheimer's disease tissue to formalin fixation.},
  author={N J Pollock and John William Wood},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={1988},
  volume={36 9},
  pages={1117-21}
}
Immunohistochemistry of formalin-fixed human Alzheimer's disease (AD) tissue using an anti-tau antibody (Tau-1) reveals staining of neurofibrillary tangles (NFTs) and neuritic plaques (NPs), whereas normal axonal staining is less apparent. In this study, we used a combined biochemical and histochemical approach to assess effects of formalin on immunoreactivity of AD tau. Nitrocellulose blots were treated with fixative to mimic conditions used with tissue sections, a method that might be… CONTINUE READING

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