Differential sensitivity of rat kidney and liver to fumonisin toxicity: organ-specific differences in toxin accumulation and sphingoid base metabolism.

@article{Riley2006DifferentialSO,
  title={Differential sensitivity of rat kidney and liver to fumonisin toxicity: organ-specific differences in toxin accumulation and sphingoid base metabolism.},
  author={Ronald T. Riley and Kenneth Voss},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2006},
  volume={92 1},
  pages={335-45}
}
Fumonisins (FBs) are mycotoxins in maize and are inhibitors of ceramide synthase (CS), the most likely proximate cause of FB toxicity. In liver and kidney, the primary target organs in FB-fed rats, inhibition of CS results in a marked increase in the ceramide precursor sphinganine (Sa). This study was conducted to investigate the differential time- and dose-dependent changes in Sa, sphingosine (So), sphinganine 1-phosphate (Sa-1-P), and sphingosine 1-phosphate (So-1-P) in kidney, liver, serum… CONTINUE READING
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Serum Sphingosine-1Phosphate and Sphinganine-1-Phosphate Are Elevated in Horses Exposed

  • P. D. Constable, R. T. Riley, +5 authors W. M. Haschek
  • Proc. Natl. Acad. Sci. U.S.A
  • 2005
Highly Influential
6 Excerpts

Effects of exogenous sphinganine, sphingosine, and sphingosine-1-phosphate on relaxation and contraction of porcine thoracic aortic and pulmonary arterial rings

  • Hsiao, S.-H., P. D. Constable, G. W. Smith, W. M. Haschek
  • Toxicol. Sci. 86, 194–199.
  • 2005
3 Excerpts

An introduction to plant sphingolipids and a review of recent advances in understanding their metabolism and function

  • D. V. Lynch, T. M. Dunn
  • New Phytol. 161, 677–702.
  • 2004
2 Excerpts

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