Differential sensitivity of organic anion transporters in rat renal brush-border membrane to diethyl pyrocarbonate.

@article{Takano1994DifferentialSO,
  title={Differential sensitivity of organic anion transporters in rat renal brush-border membrane to diethyl pyrocarbonate.},
  author={Mikihisa Takano and Junya Nagai and Teruo Okano and K Hirozane and Masahiro Yasuhara and Ryohei Hori},
  journal={Biochimica et biophysica acta},
  year={1994},
  volume={1192 2},
  pages={190-6}
}
The effect of various chemical modifiers on p-aminohippurate (PAH) uptake by a potential-sensitive system and by an anion exchanger was studied in rat renal brush-border membrane vesicles. Among various chemical modifiers, diethyl pyrocarbonate (DEPC) selectively inhibited potential-sensitive PAH uptake but not the uptake by the anion exchanger. The inhibitory effect of DEPC on potential-sensitive PAH uptake was not due to the facilitated dissipation of membrane potential, which was evidenced… CONTINUE READING