Differential sensitivity of male and female mouse embryos to oxidative induced heat-stress is mediated by glucose-6-phosphate dehydrogenase gene expression.

@article{PrezCrespo2005DifferentialSO,
  title={Differential sensitivity of male and female mouse embryos to oxidative induced heat-stress is mediated by glucose-6-phosphate dehydrogenase gene expression.},
  author={Miriam P{\'e}rez-Crespo and Miguel A Ram{\'i}rez and Ra{\'u}l Fern{\'a}ndez-Gonz{\'a}lez and Dimitrios Rizos and Patrick Lonergan and Bel{\'e}n Pintado and Alfonso Guti{\'e}rrez-Ad{\'a}n},
  journal={Molecular reproduction and development},
  year={2005},
  volume={72 4},
  pages={
          502-10
        }
}
During the preimplantation period, in vitro cultured males have a higher metabolic rate, different gene expression, and grow faster than females. It has been suggested that under some stress conditions male embryos are more vulnerable than females; however, the biological fragility of male embryos is little understood. Since many forms of stress result in the overproduction of cellular reactive oxygen species (ROS), we addressed the hypothesis that the connection between female advantage during… CONTINUE READING
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