Differential sensitivity of inward rectifier K+ channels to metabolic inhibitors.

@article{Collins2002DifferentialSO,
  title={Differential sensitivity of inward rectifier K+ channels to metabolic inhibitors.},
  author={Anthony Eugene Collins and Maureen K. Larson},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 39},
  pages={35815-8}
}
Inhibition of inward rectifier K(+) channels under ischemic conditions may contribute to electrophysiological consequences of ischemia such as cardiac arrhythmia. Ischemia causes metabolic inhibition, and the use of metabolic inhibitors is one experimental method of simulating ischemia. The effects of metabolic inhibitors on the activity of inward rectifier K(+) channels K(ir)2.1, K(ir)2.2, and K(ir)2.3 were studied by heterologous expression in Xenopus oocytes and two-electrode voltage clamp… CONTINUE READING