Differential sensitivity of human monocytes and macrophages to ANP: a role of intracellular pH on reactive oxygen species production through the phospholipase involvement.

@article{Baldini2003DifferentialSO,
  title={Differential sensitivity of human monocytes and macrophages to ANP: a role of intracellular pH on reactive oxygen species production through the phospholipase involvement.},
  author={Patrizia Morena Baldini and Paolo De Vito and Angelo De Martino and Maurizio Fraziano and Claudia Grimaldi and Paolo Luly and Francesca Zalfa and Vittorio Colizzi},
  journal={Journal of leukocyte biology},
  year={2003},
  volume={73 4},
  pages={502-10}
}
Atrial natriuretic peptide (ANP), a cardiovascular hormone, elicits different biological actions in the immune system. The aim of the present work was to study the effect of ANP on the intracellular pH (pHi) of human monocytes and macrophages and to investigate whether pHi changes could play a role on phospholipase activities and reactive oxygen species (ROS) production. Human macrophages isolated by peripheral blood mononuclear cells and THP-1 monocytes, which were shown to express all three… CONTINUE READING