Differential sensitivity of Chinese hamster V79 and Chinese hamster ovary (CHO) cells in the in vitro micronucleus screening assay.

@article{Erexson2001DifferentialSO,
  title={Differential sensitivity of Chinese hamster V79 and Chinese hamster ovary (CHO) cells in the in vitro micronucleus screening assay.},
  author={Gregory L. Erexson and Mar{\'i}a Victoria Periago and Carol Spicer},
  journal={Mutation research},
  year={2001},
  volume={495 1-2},
  pages={75-80}
}
Both the V79 and CHO cell lines are routinely used in the in vitro MN screening assay for the detection of possible genotoxicants. The CHO cell line is the predominant cell line currently used in the genetic toxicology testing industry. However, some laboratories routinely utilize the V79 cell line since the in vitro MN screening assay was initially developed using V79 cells. Our laboratory has historically used the CHO cell line. Therefore, our laboratory was interested in comparing the two… CONTINUE READING

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