Differential sensitivities of mammalian neuronal and muscle nicotinic acetylcholine receptors to general anesthetics.

@article{Violet1997DifferentialSO,
  title={Differential sensitivities of mammalian neuronal and muscle nicotinic acetylcholine receptors to general anesthetics.},
  author={Jacob Violet and David L. Downie and Ramin Charles Nakisa and William Robert Lieb and Nicholas P Franks},
  journal={Anesthesiology},
  year={1997},
  volume={86 4},
  pages={
          866-74
        }
}
BACKGROUND Nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of fast neurotransmitter-gated receptor channels that includes the gamma-aminobutyric acidA (GABAA), glycine and serotonin type 3 (5-HT3) receptors. Most previous work on the interactions of general anesthetics with nAChRs has involved the muscle-type receptor. The authors investigate the effects of general anesthetics on defined mammalian neuronal and muscle nAChRs expressed in Xenopus oocytes. METHODS… CONTINUE READING

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