Differential selectivity in carbamazepine-induced inactivation of cytochrome P450 enzymes in rat and human liver

@article{Masubuchi2001DifferentialSI,
  title={Differential selectivity in carbamazepine-induced inactivation of cytochrome P450 enzymes in rat and human liver},
  author={Yasuhiro Masubuchi and Tomohisa Nakano and Atsushi Ose and Toshiharu Horie},
  journal={Archives of Toxicology},
  year={2001},
  volume={75},
  pages={538-543}
}
Oxidative metabolism of carbamazepine results in covalent binding of its reactive metabolite to liver microsomal proteins, which has been proposed as an important event in pathogenesis of the hypersensitivity reactions to this drug. Although the proposed reactive metabolites are produced by cytochrome P450 enzymes (P450 or CYP), the impact of the formation of unstable metabolites on the enzyme itself has not been elucidated. The present study examines the alteration of P450 enzyme activities… CONTINUE READING