Differential segregation in a cell-cell contact interface: the dynamics of the immunological synapse.

@article{Burroughs2002DifferentialSI,
  title={Differential segregation in a cell-cell contact interface: the dynamics of the immunological synapse.},
  author={Nigel J. Burroughs and Christoph W{\"u}lfing},
  journal={Biophysical journal},
  year={2002},
  volume={83 4},
  pages={
          1784-96
        }
}
Receptor-ligand couples in the cell-cell contact interface between a T cell and an antigen-presenting cell form distinct geometric patterns and undergo spatial rearrangement within the contact interface. Spatial segregation of the antigen and adhesion receptors occurs within seconds of contact, central aggregation of the antigen receptor then occurring over 1-5 min. This structure, called the immunological synapse, is becoming a paradigm for localized signaling. However, the mechanisms driving… CONTINUE READING
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