Differential secretome analysis of cancer-associated fibroblasts and bone marrow-derived precursors to identify microenvironmental regulators of colon cancer progression.

@article{Boeck2013DifferentialSA,
  title={Differential secretome analysis of cancer-associated fibroblasts and bone marrow-derived precursors to identify microenvironmental regulators of colon cancer progression.},
  author={Astrid De Boeck and An Hendrix and Dawn M. Maynard and Mieke Van Bockstal and Annick Dani{\"e}ls and Patrick Pauwels and Christian P Gespach and Marc E. Bracke and Olivier De Wever},
  journal={Proteomics},
  year={2013},
  volume={13 2},
  pages={379-88}
}
The identification of cancer-associated fibroblast (CAF)-derived proteins that mediate interactions between the tumor stroma and cancer cells is a crucial step toward the discovery of new molecular targets for therapy or molecular signatures that improve tumor classification and predict clinical outcome. CAF are α-smooth muscle actin positive, representing a myofibroblast phenotype that may differentiate from multiple precursor cells, including bone marrow-derived mesenchymal stem cells (MSC… CONTINUE READING
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