Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes.

@article{Mei2011DifferentialRO,
  title={Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes.},
  author={Shuang Mei and H Ni and Sharon J. Manley and Abigail B Bockus and Karen M. Kassel and James P. Luyendyk and Bryan L. Copple and W Ding},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2011},
  volume={339 2},
  pages={487-98}
}
Fatty acid-induced lipotoxicity plays a critical role in the pathogenesis of nonalcoholic liver disease. Saturated fatty acids and unsaturated fatty acids have differential effects on cell death and steatosis, but the mechanisms responsible for these differences are not known. Using cultured HepG2 cells and primary mouse hepatocytes, we found that unsaturated and saturated fatty acids differentially regulate autophagy and apoptosis. The unsaturated fatty acid, oleic acid, promoted the formation… CONTINUE READING