Differential roles of tumor necrosis factor-α and interleukin-1 β in lipopolysaccharide-induced brain injury in the neonatal rat

@article{Cai2003DifferentialRO,
  title={Differential roles of tumor necrosis factor-α and interleukin-1 β in lipopolysaccharide-induced brain injury in the neonatal rat},
  author={Zhengwei Cai and Yi Pang and Shuying Lin and Philip G. Rhodes},
  journal={Brain Research},
  year={2003},
  volume={975},
  pages={37-47}
}
Abstract Increasing data provide support for the hypothesis that inflammatory cytokines mediate inflammation-induced injury to developing white matter. In the present study, roles of tumor necrosis factor-α (TNFα) and interleukin-1 β (IL-1β) in mediating lipopolysaccharide (LPS)-induced brain injury were investigated by co-administration of LPS with IL-1 receptor antagonist (IL-1ra) or TNFα antibody in the 5-day-old rat brain. Intracerebral injection of LPS and other agents was performed in a… CONTINUE READING

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