Differential roles of tryptophan residues in the functional expression of human anion exchanger 1 (AE1, Band 3, SLC4A1).

Abstract

Anion exchanger 1 (AE1) is a 95 kDa glycoprotein that facilitates Cl(-)=HCO(-)(3) exchange across the erythrocyte plasma membrane. This transport activity resides in the 52 kDa C-terminal membrane domain (Gly(361)-Val(911)) predicted to span the membrane 14 times. To explore the role of tryptophan (Trp) residues in AE1 function, the seven endogenous Trp… (More)
DOI: 10.3109/09687688.2014.955829

Topics

12 Figures and Tables

Cite this paper

@article{Okawa2014DifferentialRO, title={Differential roles of tryptophan residues in the functional expression of human anion exchanger 1 (AE1, Band 3, SLC4A1).}, author={Yuka Okawa and Jing Li and Arghya Basu and Joseph R Casey and Reinhart A. F. Reithmeier}, journal={Molecular membrane biology}, year={2014}, volume={31 7-8}, pages={211-27} }