Differential roles of resident microglia and infiltrating monocytes in murine CNS autoimmunity

@article{Shemer2015DifferentialRO,
  title={Differential roles of resident microglia and infiltrating monocytes in murine CNS autoimmunity},
  author={Anat Shemer and Steffen Jung},
  journal={Seminars in Immunopathology},
  year={2015},
  volume={37},
  pages={613-623}
}
Macrophages can be of dual origin. Most tissue-resident macrophage compartments are generated before birth and subsequently maintain themselves independently from each other locally in healthy tissue. Under inflammatory conditions, these cells can however be complemented by macrophages derived from acute monocyte infiltrates. Due to the lack of suitable experimental systems, differential functional contributions of central nervous system (CNS)-resident microglia and monocyte-derived macrophages… CONTINUE READING
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