Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep.

@article{Mieda2011DifferentialRO,
  title={Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep.},
  author={Michihiro Mieda and Emi Hasegawa and Yaz Y. Kisanuki and Christopher M. Sinton and Masashi Yanagisawa and Takeshi Sakurai},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 17},
  pages={6518-26}
}
Orexin-A and orexin-B are hypothalamic neuropeptides that play critical roles in the maintenance of wakefulness. Intracerebroventricular (ICV) administration of orexin-A has been shown to promote wakefulness and suppress both rapid eye movement (REM) sleep and non-REM (NREM) sleep through the orexin receptor-1 (OX(1)R) and orexin receptor-2 (OX(2)R). Here, we elucidated the differential roles of orexin receptors in the regulation of sleep and wakefulness by comparing the effects of ICV orexin-A… CONTINUE READING

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