Differential roles of nitric oxide and oxygen radicals in chondrocytes affected by osteoarthritis and rheumatoid arthritis.

@article{Mazzetti2001DifferentialRO,
  title={Differential roles of nitric oxide and oxygen radicals in chondrocytes affected by osteoarthritis and rheumatoid arthritis.},
  author={Ilaria Mazzetti and Brunella Grigolo and Lia Pulsatelli and Paolo Dolzani and Tania Silvestri and Livia Roseti and Riccardo Melic{\`o}ni and Andrea Facchini},
  journal={Clinical science},
  year={2001},
  volume={101 6},
  pages={593-9}
}
Osteoarthritis and rheumatoid arthritis are characterized by focal loss of cartilage due to an up-regulation of catabolic pathways, induced mainly by pro-inflammatory cytokines, such as interleukin-1 (IL-1) and tumour necrosis factor alpha (TNFalpha). Since reactive oxygen species are also involved in this extracellular-matrix-degrading activity, we aimed to compare the chondrocyte oxidative status responsible for cartilage damage occurring in primarily degenerative (osteoarthritis) and… CONTINUE READING

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The role of nitric oxide in articular cartilage damage.

Rheumatic diseases clinics of North America • 1999

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