Differential roles of monkey striatum in learning of sequential hand movement

  title={Differential roles of monkey striatum in learning of sequential hand movement},
  author={Shigehiro Miyachi and Okihide Hikosaka and K. Miyashita and Zolt{\'a}n Kar{\'a}di and Miya K. Rand},
  journal={Experimental Brain Research},
Abstract To study the role of the basal ganglia in learning of sequential movements, we trained two monkeys to perform a sequential button-press task (2×5 task). This task enabled us to examine the process of learning new sequences as well as the execution of well-learned sequences repeatedly. We injected muscimol (a GABA agonist) into different parts of the striatum to inactivate the local neural activity reversibly. The learning of new sequences became deficient after injections in the… 

Role of monkey cerebellar nuclei in skill for sequential movement.

The results suggest that, among the cerebellar nuclei, the dentate nucleus, especially its dorsal and central regions, is related to the storage and/or retrieval of long-term memory for motor skill.

Effects of local inactivation of monkey medial frontal cortex in learning of sequential procedures.

It is suggested that the medial frontal cortex, especially pre-SMA, is related to the acquisition, rather than the storage or execution, of the correct order of button presses.

The Sensorimotor Striatum Is Necessary for Serial Order Learning

  • H. Yin
  • Psychology, Biology
    The Journal of Neuroscience
  • 2010
Results demonstrate for the first time a critical role of the sensorimotor striatum in the learning of serial order in mice using a two-action sequence task without instructive cues.

The striatum multiplexes contextual and kinematic information to constrain motor habits execution

It is concluded that, after learning, the DLS continuously integrates task-relevant information to constrain the execution of motor habits and provides a straightforward mechanism by which the basal ganglia may contribute to habit formation and motor control.

Double dissociation of fMRI activity in the caudate nucleus supports de novo motor skill learning

A novel human fMRI experiment in which participants learned to control a computer cursor on a screen by manipulating their right fingers discovered a double dissociation of fMRI activities in the rostral and caudal caudate nucleus, which were associated with skill performance in the early and late stages of learning.

Role of [corrected] nigrostriatal dopamine system in learning to perform sequential motor tasks in a predictive manner.

The striatum and its nigrostriatal afferents function in the initial learning underlying performance of sequences of movements as single motor programs, and lesions of the nigrostiatal system spare the ability to relearn the previously acquired programs.

The Role of Striatum in Initiation and Execution of Learned Action Sequences in Rats

Evidence is provided implicating dorsal striatum in higher-level organizational aspects of learning reflected in planning that precedes the execution of learned action sequences and the relationship between the extent of dorsal striatal damage and the ability to respond to brief luminance cues and to initiate learned sequences is confirmed.

Recurrent inhibition in striatum enables transfer of time-flexible skills to basal ganglia

A model of the striatum, the major input structure of the basal ganglia, in which recurrently connected inhibitory neurons receive cortical input is developed, which allows the model to learn a sparse, sequential pattern of neural activity similar to the patterns observed in experimental population recordings.

Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill

It is demonstrated that region- and pathway-specific plasticity sculpts the circuits involved in the performance of the skill as it becomes automatized.



Eye movements in monkeys with local dopamine depletion in the caudate nucleus. I. Deficits in spontaneous saccades

The results suggest that the local deprivation of the dopaminergic innervation in the caudate nucleus facilitates neuronal activity of the SNr leading to suppression of saccadic eye movements.

Learning of sequential movements in the monkey: process of learning and retention of memory.

The results suggest that motor memory can be retained longer than procedural memory (measured by performance time) in monkeys required to learn many hypersets, in which they performed gradually better with more experiences in the 2 x 5 task.

A Neostriatal Habit Learning System in Humans

This double dissociation shows that the limbic-diencephalic regions damaged in amnesia and the neostriatum damaged in Parkinson's disease support separate and parallel learning systems.

Anticipatory saccades in sequential procedural learning in monkeys.

It is reported that the pattern of eye movements changed along with the long-term learning of sequential procedures in monkeys, suggesting that critical for the skilled performance was the combination of the eyes and the side of the hand that was used for the practice of a given sequence.

A Model of Corticostriatal Plasticity for Learning Oculomotor Associations and Sequences

Abstract We present models that learn context-dependent oculomotor behavior in (1) conditional visual discrimination and (2) sequence reproduction tasks, based on the following three principles: (1)

D1 dopamine receptors in prefrontal cortex: involvement in working memory

D1 dopamine receptors play a selective role in the mnemonic, predictive functions of the primate prefrontal cortex, and local injections of SCH23390 and SCH39166 induced errors and increased latency in performance on an oculomotor task that required memory-guided saccades.

Distributed but convergent ordering of corticostriatal projections: analysis of the frontal eye field and the supplementary eye field in the macaque monkey

There is convergence of oculomotor information from two distinct regions of the frontal cortex to the striatal matrix, which is known to project into pallidonigral circuits including the striatonigrocollicular pathway of the saccadic eye movement system.

Procedural learning and neostriatal dysfunction in man.

Patients with early stage Parkinson's disease are shown to be selectively impaired in a cognitive task of procedural learning while remaining intact in recall and recognition tests of declarative memory, thus demonstrating a double dissociation.

The Acquisition of Motor Behavior in Vertebrates

Part 1 Reflex adaptation: learning and memory in the vestibuloocular reflex, Stephen G. Lisberger the evolution of hindbrain visual and vestibular innovations responsible for oculomotor function,

Multiple output channels in the basal ganglia.

Retrograde transneuronal transport of herpes simplex virus type 1 was used to examine the organization of connections in the cebus monkey between an output nucleus of the basal ganglia, the internal segment of the globus pallidus, and three cortical areas: the primary motor cortex, the supplementary motor ara, and the ventral premotor area.