Differential roles of monkey striatum in learning of sequential hand movement

@article{Miyachi1997DifferentialRO,
  title={Differential roles of monkey striatum in learning of sequential hand movement},
  author={Shigehiro Miyachi and Okihide Hikosaka and K. Miyashita and Zolt{\'a}n Kar{\'a}di and Miya K. Rand},
  journal={Experimental Brain Research},
  year={1997},
  volume={115},
  pages={1-5}
}
Abstract To study the role of the basal ganglia in learning of sequential movements, we trained two monkeys to perform a sequential button-press task (2×5 task). This task enabled us to examine the process of learning new sequences as well as the execution of well-learned sequences repeatedly. We injected muscimol (a GABA agonist) into different parts of the striatum to inactivate the local neural activity reversibly. The learning of new sequences became deficient after injections in the… Expand
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References

SHOWING 1-10 OF 35 REFERENCES
Eye movements in monkeys with local dopamine depletion in the caudate nucleus. I. Deficits in spontaneous saccades
TLDR
The results suggest that the local deprivation of the dopaminergic innervation in the caudate nucleus facilitates neuronal activity of the SNr leading to suppression of saccadic eye movements. Expand
Learning of sequential movements in the monkey: process of learning and retention of memory.
TLDR
The results suggest that motor memory can be retained longer than procedural memory (measured by performance time) in monkeys required to learn many hypersets, in which they performed gradually better with more experiences in the 2 x 5 task. Expand
A Neostriatal Habit Learning System in Humans
TLDR
This double dissociation shows that the limbic-diencephalic regions damaged in amnesia and the neostriatum damaged in Parkinson's disease support separate and parallel learning systems. Expand
Anticipatory saccades in sequential procedural learning in monkeys.
TLDR
It is reported that the pattern of eye movements changed along with the long-term learning of sequential procedures in monkeys, suggesting that critical for the skilled performance was the combination of the eyes and the side of the hand that was used for the practice of a given sequence. Expand
A Model of Corticostriatal Plasticity for Learning Oculomotor Associations and Sequences
We present models that learn context-dependent oculomotor behavior in (1) conditional visual discrimination and (2) sequence reproduction tasks, based on the following three principles: (1) VisualExpand
D1 dopamine receptors in prefrontal cortex: involvement in working memory
TLDR
D1 dopamine receptors play a selective role in the mnemonic, predictive functions of the primate prefrontal cortex, and local injections of SCH23390 and SCH39166 induced errors and increased latency in performance on an oculomotor task that required memory-guided saccades. Expand
Distributed but convergent ordering of corticostriatal projections: analysis of the frontal eye field and the supplementary eye field in the macaque monkey
TLDR
There is convergence of oculomotor information from two distinct regions of the frontal cortex to the striatal matrix, which is known to project into pallidonigral circuits including the striatonigrocollicular pathway of the saccadic eye movement system. Expand
Procedural learning and neostriatal dysfunction in man.
TLDR
Patients with early stage Parkinson's disease are shown to be selectively impaired in a cognitive task of procedural learning while remaining intact in recall and recognition tests of declarative memory, thus demonstrating a double dissociation. Expand
The Acquisition of Motor Behavior in Vertebrates
Part 1 Reflex adaptation: learning and memory in the vestibuloocular reflex, Stephen G. Lisberger the evolution of hindbrain visual and vestibular innovations responsible for oculomotor function,Expand
Dorsolateral prefrontal lesions and oculomotor delayed-response performance: evidence for mnemonic "scotomas"
TLDR
The present results strengthen the evidence that the delayed-response deficits of monkeys with prefrontal lesions are caused by failure to maintain a transient memory “trace” in working memory, and indicate for the first time that working memory mechanisms are lateralized: memories for visuo- spatial coordinates in each hemifield are processed primarily in the contralateral prefrontal cortex. Expand
...
1
2
3
4
...