Differential roles of monkey striatum in learning of sequential hand movement

  title={Differential roles of monkey striatum in learning of sequential hand movement},
  author={Shigehiro Miyachi and Okihide Hikosaka and K. Miyashita and Zolt{\'a}n Kar{\'a}di and Miya K. Rand},
  journal={Experimental Brain Research},
Abstract To study the role of the basal ganglia in learning of sequential movements, we trained two monkeys to perform a sequential button-press task (2×5 task). This task enabled us to examine the process of learning new sequences as well as the execution of well-learned sequences repeatedly. We injected muscimol (a GABA agonist) into different parts of the striatum to inactivate the local neural activity reversibly. The learning of new sequences became deficient after injections in the… 
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