Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes.

@article{Patel2005DifferentialRO,
  title={Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes.},
  author={Sunita R. Patel and Jennifer L. Richardson and Harald Schulze and Eden Kahle and Niels Galjart and Ksenija Drabek and Ramesh A. Shivdasani and John H. Hartwig and Joseph E. Italiano},
  journal={Blood},
  year={2005},
  volume={106 13},
  pages={4076-85}
}
Megakaryocytes are terminally differentiated cells that, in their final hours, convert their cytoplasm into long, branched proplatelets, which remodel into blood platelets. Proplatelets elongate at an average rate of 0.85 microm/min in a microtubule-dependent process. Addition of rhodamine-tubulin to permeabilized proplatelets, immunofluorescence microscopy of the microtubule plus-end marker end-binding protein 3 (EB3), and fluorescence time-lapse microscopy of EB3-green fluorescent protein… CONTINUE READING
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